The rise of single?cell proteomics
نویسندگان
چکیده
Mass spectrometry-based proteomics comprehensively defines proteome expression patterns in thousands of cells majorly contributing to our current understanding many biological processes. More recently, single-cell transcriptome and genome studies, however, have demonstrated overwhelming heterogeneity tissues cellular subpopulations. These studies indicated different functionality identity, which are mainly driven by proteins their posttranscriptional modifications. The rapidly emerging field aims at complementing data generating comparative protein profiles from individual cells. Recent developments tremendous improvements sample preparation workflows MS instrumentation, quantifying over 1000 a single cell. Efficient reproducible processing conjunction with sensitive acquisition strategies will allow further increase the coverage resolution. required throughput reliability such still subject developments. Therefore, we herein discuss recent progress on specialized instrumentation next advancements outside field, expect contribute development comprehensive proteomics.
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ژورنال
عنوان ژورنال: Analytical science advances
سال: 2021
ISSN: ['2628-5452']
DOI: https://doi.org/10.1002/ansa.202000152